منابع مشابه
Xanthine oxidase inhibitors in ischaemic heart disease
Increased uric acid levels are correlated with cardiovascular disease, particularly with ischaemic heart disease. Xanthine oxidase inhibitors, especially allopurinol, lower the risk of ischaemic heart disease due to their effects on reactive oxygen species and endothelial function. In chronic stable angina pectoris, allopurinol increases the median time to ST depression, time to chest pain, and...
متن کاملFurther studies with xanthine oxidase inhibitors.
The osidase and dehydrogenase activities in the enzymes oxidizing xanthine can be differentiated by the use of certain inhibitors (1). The present study was designed to see if such inhibitors are specific for the reaction with oxygen, or whether these agents also block the transfer of electrons to cytochrome c and nitrate. Both reduced diphosphopyridine nucleotide and hypoxanthine were studied ...
متن کاملAnalysis of Xanthine Oxidase Inhibitors from Clerodendranthus spicatus with Xanthine Oxidase Immobilized Silica Coated Fe3O4 Nanoparticles
In this study, xanthine oxidase immobilized silica coated Fe3O4 nanoparticles (Fe3O4@SiO2-XO) were successfully prepared and characterized by transmission electron microscope, X-ray powder diffraction, Fourier transform infrared spectroscopy and vibrating sample magnetometer. The average diameter of the Fe3O4 nanoparticles was about 300 nm to 350 nm with a shell thickness of 60 nm. The maximum ...
متن کاملPyrazolopyrimidines as inhibitors and substrates of xanthine oxidase.
A variety of purine and azapurine analogues have been shown to serve as substrates for and inhibitors of xanthine oxidase. Thus, in addition to its usual substrates, hypoxanthine and xanthine, and its demonstrated activity on certain pterines (I), pyrimidines (2)) and aldehydes (3), the following purine analogues are oxidized by xanthine oxidase: adenine (4), 2-azaadenine (5), 6-mercaptopurine ...
متن کاملImidazo-1,2,3-triazines as substrates and inhibitors for xanthine oxidase.
A new group of compounds analogous to the purines was recently described (1) in which carbon atom 2 of the purine ring was replaced by nitrogen. One of these imidazo-1 ,2,3-triazines (I), conveniently called 2-azaadenine, was shown to be an antagonist of hypoxanthine and of adenine in its toxic action against bacteria and mice. The corresponding hydroxy compound, 2-azahypoxanthine, was relative...
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ژورنال
عنوان ژورنال: International Journal of Immunopathology and Pharmacology
سال: 2018
ISSN: 2058-7384,2058-7384
DOI: 10.1177/2058738418772210